I-prenyl transferase

IKATI #	Igama Lomkhiqizo	Incazelo
CPD3233	I-AZD-3409	I-AZD-3409 iyi-prenyl transferase inhibitor enamandla. I-AZD-3409 ibonise amandla aphezulu kune-lonafarnib. Isilinganiso se-IC(50) se-cytotoxicity ye-AZD3409 sasingu-510 kumaseli e-MEF, angu-10,600 kumaseli e-A549 kanye nezi-6,170 kumaseli e-MCF7, ngokulandelana. Kulawa maseli, i-IC(50) yomsebenzi we-FTase we-AZD3409 isuka ku-3.0 iye ku-14.2 nM kanye ne-lonafarnib isuka ku-0.26 iye ku-31.3 nM. I-AZD3409 ivimbela i-farnesylation ngezinga eliphezulu kune-geronylgeranylation. Kokubili ukuvinjelwa kwe-farnesylation kanye ne-geranylgeranylation akukwazanga ukuhlotshaniswa nomsebenzi we-antiproliferative womuthi. I-AZD3409 ingase isebenze ku-gefitinib-resistant Breast carcinoma.