I-AZD-3409

Igama Lekhemikhali:

(S)-isopropyl 2-(2-(4-fluorophenethyl)-5-((((2S,4S)-4-(nicotinoylthio)pyrrolidin-2-yl)methyl)amino)benzamido)-4-(methylthio) butanoate

Ikhodi ye-SMILES:

O=C(OC(C)C)[C@@H](NC(C1=CC(NC[C@H]2NC[C@@H](SC(C3=CN=CC=C3)=O) C2)=CC=C1CCC4=CC=C(F)C=C4)=O)CCSC

Ikhodi ye-InChi:

I-InChI=1S/C34H41FN4O4S2/c1-22(2)43-33(41)31(14-16-44-3)39-32(40)30-18-27(13-10-24(30)9- 6-23-7-11-26(35)12-8-23)37-20-28-17-29(21-38-28)45-34(42)25-5-4-15-36- 19-25/h4-5,7-8,10-13,15,18-19,22,28-29,31,37-38H,6,9,14,16-17,20-21H2,1- 3H3,(H,39,40)/t28-,29-,31-/m0/s1

I-InChi Key:

HKGUHEGKBLYKHY-QMOZSOIISA-N

Igama elingukhiye:

I-AZD3409; I-AZD-3409; I-AZD 3409

Ukunyibilika: 

Isitoreji: 

Incazelo:

I-AZD-3409 iyi-prenyl transferase inhibitor enamandla. I-AZD-3409 ibonise amandla aphezulu kune-lonafarnib. Isilinganiso se-IC(50) se-cytotoxicity ye-AZD3409 sasingu-510 kumaseli e-MEF, angu-10,600 kumaseli e-A549 kanye nezi-6,170 kumaseli e-MCF7, ngokulandelana. Kulawa maseli, i-IC(50) yomsebenzi we-FTase we-AZD3409 isuka ku-3.0 iye ku-14.2 nM kanye ne-lonafarnib isuka ku-0.26 iye ku-31.3 nM. I-AZD3409 ivimbela i-farnesylation ngezinga eliphezulu kune-geronylgeranylation. Kokubili ukuvinjelwa kwe-farnesylation kanye ne-geranylgeranylation akukwazanga ukuhlotshaniswa nomsebenzi we-antiproliferative womuthi. I-AZD3409 ingase isebenze ku-gefitinib-resistant Breast carcinoma.

Ithagethi: i-prenyl transferase inhibitor