I-OTS964

Igama Lekhemikhali:

(R)-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one

Ikhodi ye-SMILES:

[H]Cl.O=C1NC2=C(C(C3=CC=C([C@@H](C)CN(C)C)C=C3)=C(O)C=C2C)C4=C1SC =C4

Ikhodi ye-InChi:

I-InChI=1S/C23H24N2O2S.ClH/c1-13-11-18(26)19(16-7-5-15(6-8-16)14(2)12-25(3)4)20-17- 9-10-28-22(17)23(27)24-21(13)20;/h5-11,14,26H,12H2,1-4H3,(H,24,27);1H/t14-; /m0./s1

I-InChi Key:

YHPWOYBWUWSJDW-UQKRIMTDSA-N

Igama elingukhiye:

I-OTS 964, OTS-964, OTS964, 1338545-07-5

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga)

Incazelo:

I-OTS964 iyi-inhibitor ye-lymphokine-activated killer T cell-originated protein kinase (TOPK; IC50 = 28 nM). Ivimbela ngokuqondile i-cytokinesis, okuholela ku-apoptosis, kuhlu olubanzi lwamaseli omdlavuza. I-OTS964 yenza i-apoptosis yamaseli omdlavuza wamaphaphu womuntu kuma-xenografts wamagundane.

Ithagethi: TOPK