I-Etoricoxib

Igama Lekhemikhali:

5-Chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine

Ikhodi ye-SMILES:

O=S(C1=CC=C(C2=CC(Cl)=CN=C2C3=CC=C(C)N=C3)C=C1)(C)=O

Ikhodi ye-InChi:

I-InChI=1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6- 13)24(2,22)23/h3-11H,1-2H3

I-InChi Key:

MNJVRJDLRVPLFE-UHFFFAOYSA-N

Igama elingukhiye:

Etoricoxib, Arcoxia, L-791456, MK 0663, MK-0663, 202409-33-4

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga)

Incazelo:

I-Etoricoxib iyisidakamizwa sokwenziwa, esingeyona i-steroidal eqeda ukuvuvukala (i-NSAID) ene-antipyretic, analgesic, kanye nezakhiwo ezingase zibe khona ze-antineoplastic. I-Etoricoxib ibophezela futhi ivimbele i-enzyme i-cyclooxygenase-2 (COX-2), okuholela ekuvinjweni kokuguqulwa kwe-arachidonic acid ibe yi-prostaglandin. Ukuvinjelwa kwe-COX-2 kungase kubangele i-apoptosis futhi kuvimbele ukwanda kwamaseli wesimila kanye ne-angiogenesis.

Ithagethi: COX-2