I-BAY-850

Igama Lekhemikhali:

N-((R)-1-(((1s,4S)-4-aminocyclohexyl)amino)-3-(4-cyanophenyl)propan-2-yl)-2-chloro-4-methoxy-5-(5 -(((R)-1-(p-tolyl)ethyl)amino)methyl)furan-2-yl)benzamide

Ikhodi ye-SMILES:

ClC(C(C(N[C@H])(CC1=CC=C(C#N)C=C1)CN[C@@H]2CC[C@H](N)CC2)=O)=C3 )=CC(OC)=C3C(O4)=CC=C4CN[C@H](C)C5=CC=C(C)C=C5

Ikhodi ye-InChi:

I-InChI=1S/C38H44ClN5O3/c1-24-4-10-28(11-5-24)25(2)42-23-32-16-17-36(47-32)34-19-33(35( 39)20-37(34)46-3)38(45)44-31(18-26-6-8-27(21-40)9-7-26)22-43-30-14-12- 29(41)13-15-30/h4-11,16-17,19-20,25,29-31,42-43H,12-15,18,22-23,41H2,1-3H3,(H ,44,45)/t25-,29-,30+,31-/m1/s1

I-InChi Key:

I-BSISGUIVBKDTQO-QIKYYPRYSA-N

Igama elingukhiye:

I-BAY-850; I-BAY850; BAY 850

Ukunyibilika:I-DMSO

Isitoreji: 

Incazelo:

"I-BAY-850 iwuphenyo lwamakhemikhali lwe-ATAD2A bromodomain esusa i-acetylated H4 peptide kusukela ku-ATAD2 bromodomain enenani le-IC50 elingu-20 nM (HTRF). Izilinganiso ze-MST ne-BROMOscan zibonisa i-Kd engu-84.9 nM no-120 nM, ngokulandelana. I-850 ibonisa ukukhetha okuhle kuzo zonke ezinye izizinda ze-bromodomain (akukho hits ku-BROMOscan kokuthi 10 µM) futhi isusa i-ATAD2 yobude obugcwele kusukela ku-chromatin kumaseli abukhoma ekuhlanganiseni okungu-1 µM njengoba kunqunywa i-FRAP Ukuze ugweme ukugxilisa okungaba khona okungaqondile okungacacisiwe kwe-≥ 5 µM akunconyiwe (http://www.thesgc.org/chemical-probes/BAY-850) "

Ithagethi: i-chemical probe ye-ATAD2A bromodomain