S-600918, Sivopixant

Orukọ Kemikali:

(2S)-3-[(4E) -3-[(4-chlorophenyl)methyl]-2,6-dioxo-4-({4-[(pyridin-2-yl)oxy]phenyl}imino)-1 ,3,5-triazinan-1-yl] -2-methylpropanoic acid

KỌỌDỌ SMILES:

O=C(O)[C@@H](C)CN1C(N(CC2=CC=C(Cl)C=C2)/C(NC1=O)=N/C3=CC=C(OC4=NC) =CC=C4)C=C3)=O

Koodu InChi:

InChi=1S/C25H22ClN5O5/c1-16(22(32)33)14-31-24(34)29-23(30(25(31)35)15-17-5-7-18(26)8- 6-17)28-19-9-11-20 (12-10-19)36-21-4-2-3-13-27-21/h2-13,16H,14-15H2,1H3,(H) ,32,33)(H,28,29,34)/t16-/m0/s1

Bọtini InChi:

SKZQFKBIJUXXCG-INIZCTEOSA-N

Koko:

2414285-40-6; CAS: 2414285-40-6; CAS: 2414285-40-6; Sivopixant; S-600918; S 600918; S600918

Solubility:Tiotuka ni DMSO

Ibi ipamọ:Gbẹ, dudu ati ni 0 - 4 C fun igba kukuru (ọjọ si awọn ọsẹ) tabi -20 C fun igba pipẹ (awọn oṣu si ọdun)

Apejuwe:

Sivopixant, ti a tun mọ ni S-600918, jẹ antagonist olugba olugba P2X3 yiyan (P2X3 IC50, 4.2 nM; P2X2/3 IC50, 1100 nM). Sivopixant ṣe afihan ipa analgesic ti o lagbara ninu eku apa kan sciatic nerve ligation model (Seltzer model) ti allodynia (ED50, 0.4 mg/kg).

Afojusun: Yiyan P2X3 antagonist olugba