ND-630
Alaye ọja
ọja Tags
| Iwọn Pack | Wiwa | Iye owo (USD) |
| 10mg | O wa | 300 |
| 50mg | O wa | 500 |
| 100mg | O wa | 800 |
| Awọn iwọn diẹ sii | Gba Awọn asọye | Gba Awọn asọye |
Orukọ Kemikali:
(R) -2- (1- (2--methoxyphenyl) -2- ((tetrahydro-2H-pyran-4-yl) oxy) ethyl) -5-methyl-6- (oxazol-2-yl) -2,4-dioxo-1,2-dihydrothieno[2,3-d] pyrimidin-3(4H) -yl)-2-methylpropanamide
KỌỌDỌ SMILES:
O=C(N)C(C)(C)N(C(N(C[C@@H])(C1=CC=CC=C1OC)OC2CCOCC2)C3=C4C(C)=C(C5=NC= CO5)S3)=O)C4=O
Koodu InChi:
InChi=1S/C28H31N3O8S/c1-16-21-24(32)31(28(2,3)26(33)34)27(35)30(25(21)40-22(16)23-29- 11-14-38-23)15-20 (39-17-9-12-37-13-10-17)18-7-5-6-8-19(18)36-4/h5-8, 11,14,17,20H,9-10,12-13,15H2,1-4H3,(H,33,34)/t20-/m0/s1
Bọtini InChi:
ZZWWXIBKLBMSCS-FQEVSTJZSA-N
Koko-ọrọ:
ND-630, ND630, ND 630, GS-0976, GS0976, GS 0976, NDI-010976, NDI010976, NDI 010976, Firsocostat, 1434635-54-7
Solubility:Tiotuka ni DMSO
Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu).
Apejuwe:
ND-630 ṣe idiwọ hACC1 (IC50 = 2.1 ± 0.2 nM) ati hACC2 (IC50 = 6.1 ± 0.8 nM). Idinamọ jẹ iyipada ati ni pato ga julọ fun ACC. ND-630 ṣe idiwọ iṣẹ ACC nipasẹ ibaraṣepọ laarin olugba phosphopeptide ati aaye dimerization ti enzymu lati ṣe idiwọ dimerization. ND-630 ṣe idiwọ iṣelọpọ acid fatty pẹlu EC50 ti 66 nM ninu awọn sẹẹli HepG2 laisi iyipada nọmba sẹẹli lapapọ, ifọkansi amuaradagba cellular, ati iṣakojọpọ acetate sinu cholesterol[1].
afojusun: ACC
