Ingliforib

Orukọ Kemikali:

5-chloro-N-((2S,3R)-4-((3S,4R)-3,4-dihydroxypyrrolidin-1-yl)-3-hydroxy-4-oxo-1-phenylbutan-2-yl)- 1H-indole-2-carboxamide

KỌỌDỌ SMILES:

O[C@H](C1)[C@@H](O)CN1C([C@H](O)[C@H](CC2=CC=CC=C2)NC(C3=CC4=C( N3)C=CC(Cl)=C4)=O)=O

Koodu InChi:

InChi=1S/C23H24ClN3O5/c24-15-6-7-16-14(9-15)10-18(25-16)22(31)26-17(8-13-4-2-1-3- 5-13)21 (30)23 (3 2)27-11-19 (28)20 (29)12-27/h1-7,9-10,17,19-21,25,28-30H,8,11-12H2,(H,26,31 ) /t17-,19-,20+,21+/m0/s1

Bọtini InChi:

GVDRRZOORHCTAN-MJUUVYJYSA-N

Koko:

Ingliforib; CP-296; CP-368; CP-368,296; CP296; CP 296; CP-368296; CP368296; CP 368296

Solubility:DMSO

Ibi ipamọ: 

Apejuwe:

Ingliforib, ti a tun mọ ni CP-368296, jẹ oludena glycogen phosphorylase aramada. Ingliforib ni antihyperglycemic ati awọn ohun-ini aabo inu ọkan. Ingliforib ṣe idiwọ glycogen phosphorylase, henensiamu aropin-oṣuwọn ni glycogenolysis, nitorinaa idilọwọ itusilẹ ti glukosi-1 fosifeti lati moleku glycogen ninu ẹdọ. Aṣoju yii tun ṣe idiwọ glycogen phosphorylase ninu iṣan ọkan ọkan ati pe o le daabobo ọkan lati ipalara ischemic myocardial nipa titọju akoonu glycogen ati imudarasi idapọ glycolytic-oxidative.

Ifojusi: phosphorylase glycogen