BMS-955176

BMS-955176
  • Orukọ:BMS-955176
  • Katalogi No.CPD3218
  • CAS No.:1392312-45-6 (ipilẹ ọfẹ) 2097784-79-5 (TFA)
  • Ìwọ̀n Molikula:690.44
  • Fọọmu Kemikali:C42H62N2O4S
  • Fun iwadi ijinle sayensi nikan, kii ṣe fun awọn alaisan.

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    Orukọ Kemikali:

    4-(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-(2-(1,1-dioxidothiomorpholino)ethyl)amino) -5a,5b,8,8,11a -pentamethyl-1 -(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro -1H-cyclopenta [a] chrysen-9-yl) benzoic acid

    KỌỌDỌ SMILES:

    O=C(O)C1=CC=C(C2=CC[C@@]3(C)[C@@](C2(C)C)([H])CC[C@@]4(C) )[C@]5(C)CC[C@](C C[C@H]6C(C)=C)(NCCN(CC7)CCS7(=O)=O)[C@@]6([H])[C@@]5([H]) CC[ C @]34[H])C=C1

    Koodu InChi:

    InChi=1S/C42H62N2O4S/c1-28(2)31-14-19-42(43-22-23-44-24-26-49(47,48)2 7-25-44)21-20-40(6)33(36(31)42)12-13-35-39(5)17-15-32(29-8-10-30(11-9) -29)37(45)46)38(3,4)34(39)16-18-41(35,40)7/h8-11,15,31,33-36,43H,1,12 -14,16-27H2,2-7H3,(H,45,46)/t31-,33+,34-,35+,36+,39-,40+,41+,42-/m0/s1

    Bọtini InChi:

    XDMUFNNPLXHNKA-ZTESCHFWSA-N

    Koko-ọrọ:

    GSK3532795, GSK-3532795, GSK 3532795, BMS-955176, BMS 955176, BMS955176

    Solubility: 

    Ibi ipamọ: 

    Apejuwe:

    GSK3532795, ti a tun mọ ni BMS-955176, jẹ agbara, ti nṣiṣe lọwọ ẹnu, oludanukokoro maturation HIV-1 iran-keji (MI) ti o ni ilọsiwaju nipasẹ awọn idanwo ile-iwosan alakoso IIb. GSK3532795 daapọ agbegbe gbooro ti awọn ọlọjẹ polymorphic (EC50<15 nM si ẹgbẹ kan ti aṣoju polymorphisms ti o wọpọ ti 96.5% HIV-1 subtype B virus) pẹlu profaili elegbogi ti o wuyi ni awọn ẹya preclinical.

    Àfojúsùn: HIV-1 inhibitor maturation (MI)


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