Tropifexor
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 100mg | Ikhona evenkileni | 800 |
| 1g | Ikhona evenkileni | 1850 |
| 5g | Ikhona evenkileni | 7400 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
2-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8- yl) -4-fluorobenzo[d]thiazole-6-carboxylic acid
Ikhowudi yoncumo:
FC(F)(F)OC(C=CC=C1)=C1C2=NOC(C3CC3)=C2CO[C@@H]4C[C@H]5N(C6=NC7=C(F)C=C( C(O)=O)C=C7S6)[C@H](CC5)C4
Ikhowudi ye-InChi:
InChI=1S/C29H25F4N3O5S/c30-21-9-15(27(37)38)10-23-25(21)34-28(42-23)36-16-7-8-17(36)12- 18(11-16)39-13-20-24(35-41-26(20)14-5-6-14)19-3-1-2-4-22(19)40-29(31, 32)33/h1-4,9-10,14,16-18H,5-8,11-13H2,(H,37,38)/t16-,17+,18+
Isitshixo se-InChi:
VYLOOGHLKSNNEK-PIIMJCKOSA-N
Igama elingundoqo:
Tropifexor, LJN-452, LJN452, LJN 452, 1383816-29-2
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).
Inkcazo:
I-Tropifexor (i-compound 1) iyinoveli kunye ne-agonist enamandla kakhulu ye-FXR kunye ne-EC50 ye-0.2 nM. Ukungeniswa okunamandla kuzo zombini i-BSEP kunye ne-SHP yofuzo kujongwa kwiiseli eziphambili yi-Tropifexor ngendlela exhomekeke kugxininiso. Ukulawulwa kwe-BSEP ngaphezu kwesithuthi (i-DMSO) kubonwa kwiindawo eziphantsi njenge-1 nM, ngelixa ukufakwa okunamandla kwe-SHP (i-15-fold ngaphaya kwesithuthi) kubonwa kwi-10 nM kunye nokunyanzeliswa okuthobekileyo kwe-SHP kwi-1 nM (3-fold) [1 ].
Ithagethi: FXR
