I-PRT-060318; I-PRT318; P142–76
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 500mg | Ikhona evenkileni | 900 |
| 1g | Ikhona evenkileni | 1350 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
2-(((1R,2S)-2-aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide
Ikhowudi yoncumo:
O=C(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(C)=C3)N
Ikhowudi ye-InChi:
InChI=1S/C18H24N6O/c1-11-5-4-6-12(9-11)22-17-13(16(20)25)10-21-18(24-17)23-15-8- 3-2-7 -14(15)19/h4-6,9-10,14-15H,2-3,7-8,19H2,1H3,(H2,20,25)(H2,21,22,23,24)/ t14-,15+/m0/s1
Isitshixo se-InChi:
NZNTWOVDIXCHHS-LSDHHAIUSA-N
Igama elingundoqo:
PRT-060318,PRT318, P142–76, PRT060318, PRT 060318, PRT318, PRT-318, PRT 318, 1194961-19-7
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga)
Inkcazo:
I-PRT060318 yi-inhibitor enamandla kwaye ekhethiweyo ye-spleen tyrosine kinase (Syk; IC50 = 4 nM) .Iyakhetha, inqanda i-92% yomsebenzi we-Syk, ngelixa ezinye i-kinases zigcina> i-70% umsebenzi, ekugxininiseni kwe-50 nM kwiqela lephaneli. 270 kinases. I-PRT060318 inqanda i-convulxin-induced aggregation ye-plasma ecebileyo yeplatelet yomntu (IC50 = 2.5 μM) kwi-vitro kwaye ikhusela i-thrombosis kwimodeli ye-mouse ye-transgenic ye-heparin-induced thrombocytopenia. Ibangela i-lymphocytic leukemia engapheliyo (CLL) i-B cell apoptosis kwaye inqanda ukukhutshwa kwee-chemokines i-CCL3, i-CCL4, kunye ne-CXCL13.3 PRT060318 iphinda inqanda i-CLL B ye-cell chemotaxis kunye ne-pseudoemperipolesis.
Ujoliso: Syk
