I-BAY 61-3606 2HCl
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 1g | Ikhona evenkileni | 1200 |
| 10g | Ikhona evenkileni | 5000 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
2-[[7-(3,4-Dimethoxyphenyl) imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide dihydrochloride
Ikhowudi yoncumo:
O=C(N)C1=C(NC2=NC(C3=CC=C(OC)C(OC)=C3)=CC4=NC=CN24)N=CC=C1.[H]Cl.[H] Cl
Ikhowudi ye-InChi:
InChI=1S/C20H18N6O3.2ClH/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20 (24-14)25-19-13(18(21)27)4-3-7-23-19;;/h3-11H,1-2H3,(H2,21,27)(H,23,24) ,25);2*1H
Isitshixo se-InChi:
SPMFELFGGPQLN-UHFFFAOYSA-N
Igama elingundoqo:
BAY 61-3606, 648903-57-5, BAY 613606, BAY-613606, BAY-61-3606
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga)
Inkcazo:
I-BAY 61-3606 inamandla (Ki = 7.5 nM) kunye ne-inhibitor ekhethiweyo ye-Syk kinase. I-BAY 61-3606 ivimbele i-degranulation kuphela (ixabiso le-IC50 phakathi kwe-5 kunye ne-46 nM) kodwa kunye nomlamli we-lipid kunye ne-cytokine synthesis kwiiseli ze-mast. I-BAY 61-3606 yayisebenza kakhulu kwi-basophils efunyenwe kwizifundo zabantu abanempilo (IC50 = 10 nM) kwaye ibonakala inamandla kakhulu kwi-basophils efunyenwe kwi-atopic (i-serum ephezulu ye-IgE) (IC50 = 8.1 nM). I-B cell receptor activation kunye ne-receptors ye-Fc inxalenye ye-IgG yokubonisa kwii-eosinophils kunye ne-monocytes nazo zanyanzeliswa ngamandla yi-BAY 61-3606.
Ujoliso: Syk
