Flibanserin

Igama leMchiza:

1-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazol-2(3H)-one hydrochloride

Ikhowudi yoncumo:

O=C1NC2=CC=CC=C2N1CCN3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3

Ikhowudi ye-InChi:

InChI=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12) -26)10-13-27-18-7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)

Isitshixo se-InChi:

PPRRDFIXUUSXRA-UHFFFAOYSA-N

Igama elingundoqo:

Flibanserin, 167933-07-5

Ukunyibilika:Inyibilika kwi-DMSO

Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).

Inkcazo:

I-Flibanserin i-agonist epheleleyo ye-5-HT1A receptor (Ki = 1 nM) kwaye, kunye nobudlelwane obuphantsi, njengomchasi we-5-HT2A receptor (Ki = 49 nM) kunye ne-antagonist okanye i-agonist ebuthathaka kakhulu ye-receptor ye-D4 ( Ki = 4–24 nM). Ngaphandle kobudlelwane obukhulu kakhulu be-flibanserin kwi-receptor ye-5-HT1A, kwaye ngenxa yezizathu ezingaziwa, i-flibanserin ithatha i-5-HT1A kunye ne-5-HT2A i-receptors kwi-vivo kunye neepesenti ezifanayo. I-Flibanserin nayo inobudlelwane obuphantsi be-5-HT2B i-receptor (Ki = 89.3 nM) kunye ne-5-HT2C i-receptor (Ki = 88.3 nM), zombini iziphatha njengomchasi. I-Flibanserin isebenzise ngokukhethekileyo i-5-HT1A i-receptors kwi-cortex yangaphambili, ebonisa ukukhethwa kwengingqi, kwaye ifunyenwe ukwandisa i-dopamine kunye ne-norepinephrine amanqanaba kunye nokunciphisa amanqanaba e-serotonin kwi-rat prefrontal cortex, izenzo eziye zamiselwa ukuba zixutywe ngokusebenza kwe-5-HT1A. umamkeli [12] Ngaloo ndlela, i-flibanserin ichazwe njenge-norepinephrine-dopamine disinhibitor (NDDI). I-Flibanserin yavunywa ngo-Agasti 2015 kunyango lwabasetyhini be-pre-menopausal abane-hypoactive sex disorder disorder (HSDD).

Ithagethi: 5HT