IACS-010759
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 100mg | Ikhona evenkileni | 300 |
| 500mg | Ikhona evenkileni | 800 |
| 1g | Ikhona evenkileni | 1200 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy) phenyl)-1,2,4-oxadiazole
Ikhowudi yoncumo:
FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC=CC(N5CCC(S(=O)(C))=O)CC5)=C4)C(C)= N3)=N2)C=C1
Ikhowudi ye-InChi:
InChI=1S/C25H25F3N6O4S/c1-16-29-23(24-30-22(32-38-24)18-6-8-20(9-7-18)37-25(26,27)28) 31-34(16)15-17-4-3-5-19(14-17)33-12-10-21(11-13-33)39(2,35)36/h3-9,14, 21H,10-13,15H2,1-2H3
Isitshixo se-InChi:
HWJWNWZJUYCGKV-UHFFFAOYSA-N
Igama elingundoqo:
IACS-010759, IACS 010759, IACS010759, IACS-10759, IACS 10759, IACS10759, 1570496-34-2, 1807523-99-4
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).
Inkcazo:
I-IACS-010759 okanye i-IACS-10759 inamandla kwaye ikhetha i-Oxidative Phosphorylation Inhibitor (IC50).< 10 nM) enomsebenzi onokubakho we-antineoplastic. IACS-010759 ibophelela kwaye inqanda ezintsonkothileyo I yekhonkco yothutho elektroni (NADH ubiquinone oxidoreductase), ngaloo ndlela ngokukhetha bahluthe iiseli ithumba izondlo, namandla, kwaye inhibiting nucleotide kunye nemveliso amino acid, nto leyo eyenza autophagy, kubangela ukufa iseli ithumba kwaye inhibits iseli. ukwanda. I-Mitochondrial complex I, ene-hyperactivated kwiiseli zomhlaza ukuhlangabezana neemfuno zabo ezongeziweyo zamandla, idlala indima ephambili ekukhuthazeni ukwanda kweeseli zomhlaza.
Ithagethi: OXPHOS