iprenyl transferase

CAT #	Igama lemveliso	Inkcazo
CPD3233	I-AZD-3409	I-AZD-3409 sisithinteli esinamandla se-prenyl transferase. I-AZD-3409 ibonise amandla aphezulu kunelonafarnib. I-IC (50) ye-cytotoxicity ye-AZD3409 yayiyi-510 kwiiseli ze-MEF, i-10,600 kwiiseli ze-A549 kunye ne-6,170 kwiiseli ze-MCF7, ngokulandelanayo. Kwezi seli, i-IC (50) yomsebenzi we-FTase we-AZD3409 ukusuka kwi-3.0 ukuya kwi-14.2 nM kunye ne-lonafarnib ukusuka kwi-0.26 ukuya kwi-31.3 nM. I-AZD3409 inqanda i-farnesylation ukuya kwinqanaba eliphezulu kune-gernylgeranylation. Zombini inhibition ye-farnesylation kunye ne-geranylgeranylation ayikwazanga ukunxibelelana nomsebenzi wokuchasana neyeza. I-AZD3409 inokuba iyasebenza kwi-gefitinib-resistant breast carcinoma.