| CAT # | Haryt ady | Düşündiriş |
| CPD3611 | SB-204990 | SB-204990, güýçli ATP sitrat-lýaza inhibitory SB-201076-nyň önümidir. SB-204990, alakalara dilden berilende ulgam aýlanyşyna siňdirilende, bagyrda SB-201076-nyň farmakologiki taýdan degişli konsentrasiýalary tapyldy. SB-204990 (günde 25 mg / kg) itdäki plazma holesteriniň derejesini (23% -e çenli) we trigliserid derejesini (38% -e çenli) peseldip, ýokary dykyzlykly lipoprotein holesterini bilen deňeşdirilende pes dykyzlykly lipoproteini peseldýär. derejeleri. SB-204990 lipid sintezi de novo üçin substrat üpjünçiligine gözegçilik etmekde möhüm ferment we gipolipidaemiki gatyşmak üçin potensial ferment nyşanydyr. |
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