BMS-955176

Himiki ady:

4 - ((1R, 3aS, 5aR, 5bR, 7aR, 11aS, 11bR, 13aR, 13bR) -3a - (((2- -pentametil-1 - (prop-1-en-2-ýyl) -2,3,3a, 4,5,5a, 5b, 6,7,7a, 8,11,11a, 11b, 12,13,13a, 13b-sekizdehidro -1H-siklopenta [a] hrizen-9 ýyl) benzoik kislotasy

SMILES kody:

O = C (O) C1 = CC = C (C2 = CC [C @@] 3 (C) [C @@] (C2 (C) C) ([H]) CC [C @@] 4 (C ) [C @] 5 (C) CC [C @] (C. C [C @ H] 6C (C) = C) (NCCN (CC7) CCS7 (= O) = O) [C @@] 6 ​​([H]) [C @@] 5 ​​([H]) CC [ C @] 34 [H]) C = C1

InChi kody:

InChI = 1S / C42H62N2O4S / c1-28 (2) 31-14-19-42 (43-22-23-44-24-26-49 (47,48) 27-25-44) 21-20-40 ( 6) 33 (36 (31) 42) 12-13-35-39 (5) 17-15-32 (29-8-10-30 (11-9) -29) 37 (45) 46) 38 (3,4) 34 (39) 16-18-41 (35,40) 7 / h8-11,15,31,33-36,43H, 1,12-14 , 16-27H2,2-7H3, (H, 45,46) / t31-, 33 +, 34-, 35 +, 36 +, 39-, 40 +, 41 +, 42- / m0 / s1

InChi açary:

XDMUFNNPLXHNKA-ZTESCHFWSA-N

Açar söz:

GSK3532795, GSK-3532795, GSK 3532795, BMS-955176, BMS 955176, BMS955176

Çözüw: 

Saklama: 

Düşündiriş:

GSK3532795, BMS-955176 diýlip hem atlandyrylýar, IIb kliniki synaglardan geçen güýçli, dilden işjeň, ikinji nesil AIW-1 ýetişmek inhibitory (MI). GSK3532795 polimorf wiruslaryň (EC50) giň ýaýramagyny birleşdirýärPrekliniki görnüşlerde amatly farmakokinetiki profil bilen, 96,5% AIW-1 görnüşli B wirusynyň umumy polimorfizm wekiline <15 nM.

Maksat: AIW-1 kämillik inhibitory (MI)