Zidesamtinib; NVL-520

Lebitso:(6R)-22-ethyl-54-fluoro-42,6-dimethyl-22H,42 H-7-oxa1(3,5)-pyridina-2(3,4)-pyrazola-4(4,5)- [1,2,3]triazola5(1,2)-benzenacycloheptaphan-16-amine

Nomoro ea lethathamo:CPD114216

Nomoro ea CAS:2739829-00-4

Boima ba Molek'hule:419.45

Foromo ea Lik'hemik'hale:C22 H22 F N7 O

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Lintlha tsa Sehlahisoa

Li-tag tsa Sehlahisoa

Boholo ba Pakete	Ho fumaneha	Theko (USD)
0.1G	E teng thepeng e teng ka lebenkeleng	390
0.5G	E teng thepeng e teng ka lebenkeleng	560
1G	E teng thepeng e teng ka lebenkeleng	850

Lebitso la lik'hemik'hale:

(6R)-22-ethyl-54-fluoro-42,6-dimethyl-22H,42 H-7-oxa1(3,5)-pyridina-2(3,4)-pyrazola-4(4,5)- [1,2,3]triazola5(1,2)-benzenacycloheptaphan-16-amine

SMILES Khouto:

FC1=CC([C@](OC2=C(N=CC3=C2)N)(C)[H])=C(C=C1)C4=NN(N=C4CC5=C3N(N=C5)CC )C

Khoutu ea InChi:

InChI=1S/C22H22FN7O/c1-4-30-21-13(11-26-30)7-18-20(28-29(3)27-18)16-6-5-15(23)9- 17 (16)12(2)31-19-8-14(21)10-25-22(19)24/h5-6,8-12H,4,7H2,1-3H3,(H2,24,25) /t12-/m1/s1

InChi Key:

DTWUUAFTYSMNQX-GFCCVEGCSA-N

Keyword:

2739829-00-4;CAS:2739829-00-4;CAS:2739829-00-4;Zidesamtinib; NVL-520; NVL520; NVL 520

Sollubility:

Polokelo:E omme, e lefifi le ho 0 - 4 C bakeng sa nako e khutšoanyane (matsatsi ho isa ho libeke) kapa -20 C bakeng sa nako e telele (likhoeli ho isa ho lilemo).

Tlhaloso:

Zidesamtinib (NVL-520) ke ntho e sebetsang hantle, e khethang, e sebetsang ka molomo, le mokoallo oa mali bokong o khonang ho kenella ka ROS1 fusion le resistance mutation inhibitor.

Sepheo: ROS1

E fetileng: (R) -(3aR,4R,6R,6aR)-6-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d [1,3]dioxol-4-yl)(4-chlorophenyl)methanol

E 'ngoe: Lirafugratinib; RLY-4008