Quarfloxin
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Lebitso la lik'hemik'hale:
5-fluoro-N-(2-((S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-((R)-3-(pyrazin-2-yl)pyrrolidin-1-yl )-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide
SMILES Khouto:
FC1=C(N2CC[C@@H](C3=CN=CC=N3)C2)C(OC4=C5C=C6C(C=CC=C6)=C4)=C(N5C=C(C(NCC[ C@H]7N(C)CCC7)=O)C8=O)C8=C1
Khoutu ea InChi:
InChI=1S/C35H33FN6O3/c1-40-13-4-7-24(40)8-10-39-35(44)26-20-42-29-15-21-5-2-3-6- 22(21)16-30(29)45-34-31(42)25(33(26)43)17-27(36)32(34)41-14-9-23(19-41)28- 18-37-11-12-38-28/h2-3,5-6,11-12,15-18,20,23-24H,4,7-10,13-14,19H2,1H3,(H ,39,44)/t23-,24+/m1/s1
InChi Key:
WOQIDNWTQOYDLF-RPWUZVMVSA-N
Keyword:
CX 3543; CX-3543; CX 3543; Quarfloxacin
Sollubility:
Polokelo:
Tlhaloso:
Quarfloxin, eo hape e tsejoang e le Quarfloxacin le CX-3543, ke motsoako oa fluoroquinolone o nang le tšebetso ea antineoplastic. Quarfloxin e senya tšebelisano pakeng tsa protheine ea nucleolin le sebopeho sa G-quadruplex DNA template ea ribosomal DNA (rDNA), tšebelisano e mahlonoko bakeng sa rRNA biogenesis e fetisitsoeng ho feta lisele tsa kankere; Tšitiso ea DNA ena ea G-quadruplex: tšebelisano ea protheine ka har'a biogenesis e sa sebetseng ea rRNA e ka fella ka ho thibeloa ha ribosome synthesis le tumor cell apoptosis.
Sepheo: