BMS-986195
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 100mg | E teng thepeng e teng ka lebenkeleng | 300 |
| 500mg | E teng thepeng e teng ka lebenkeleng | 850 |
| 1g | E teng thepeng e teng ka lebenkeleng | 1200 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
(S) -4-(3-(empa-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide
SMILES Khouto:
FC1=C(N2CCC[C@H](NC(C#CC)=O)C2)C3=C(NC(C)=C3C)C(C(N)=O)=C1
Khoutu ea InChi:
InChI=1S/C20H23FN4O2/c1-4-6-16(26)24-13-7-5-8-25(10-13)19-15(21)9-14(20(22)27)18- 17(19)11(2)12(3)23-18/h9,13,23H,5,7-8,10H2,1-3H3,(H2,22,27)(H,24,26)/t13 -/m0/s1
InChi Key:
VJPPLCNBDLZIFG-ZDUSSCGKSA-N
Keyword:
BMS-986195, BMS 986195, BMS986195, 1912445-55-6
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).
Tlhaloso:
BMS-986195 ke inhibitor e matla, e sebetsang, e ke keng ea qojoa ea Bruton's tyrosine kinase (BTK), setho sa lelapa la Tec la non-receptor tyrosine kinases ea bohlokoa bakeng sa pontšo ea B-cell e itšetlehileng ka antigen le ts'ebetsong. BMS-986195 e khetha ka makhetlo a fetang 5000 bakeng sa BTK holim'a kinase eohle e ka ntle ho lelapa la Tec, 'me khetho e tloha ho 9- ho isa ho 1010-fold ka har'a lelapa la Tec. BMS-986195 inactivated BTK maling a batho bohle ka lebelo le potlakileng la ho se sebetse (3.5 × 10-4 nM-1·min-1) le ho thibela ka matla tlhahiso ea interleukin-6 e itšetlehileng ka antigen, polelo ea CD86 le ho ata ha lisele tsa B (IC50<1 nM) ntle le phello ho mehato e ikemetseng ea antigen liseleng tse tšoanang.
Sepheo: BTK
