IACS-010759
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 100mg | E teng thepeng e teng ka lebenkeleng | 300 |
| 500mg | E teng thepeng e teng ka lebenkeleng | 800 |
| 1g | E teng thepeng e teng ka lebenkeleng | 1200 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy) phenyl) -1,2,4-oxadiazole
SMILES Khouto:
FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC=CC(N5CCC(S(=O)(C))=O)CC5)=C4)C(C)= N3)=N2)C=C1
Khoutu ea InChi:
InChI=1S/C25H25F3N6O4S/c1-16-29-23(24-30-22(32-38-24)18-6-8-20(9-7-18)37-25(26,27)28) 31-34(16)15-17-4-3-5-19(14-17)33-12-10-21(11-13-33)39(2,35)36/h3-9,14, 21H,10-13,15H2,1-2H3
InChi Key:
HWJWNWZJUYCGKV-UHFFFAOYSA-N
Keyword:
IACS-010759, IACS 010759, IACS010759, IACS-10759, IACS 10759, IACS10759, 1570496-34-2, 1807523-99-4
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).
Tlhaloso:
IACS-010759 kapa IACS-10759 ke e matla ebile e khetha Oxidative Phosphorylation Inhibitor (IC50).<10 nM) e nang le ts'ebetso e ka bang teng ea antineoplastic. IACS-010759 e tlamella le ho thibela ho rarahaneng I ea ketane ea lipalangoang tsa elektronike (NADH ubiquinone oxidoreductase), ka tsela eo e khetha ho amoha lisele tsa hlahala tsa limatlafatsi, le matla, le ho thibela tlhahiso ea nucleotide le amino acid, e leng se etsang hore motho a se ke a hlola a e-ba teng, e baka lefu la lisele tsa tumor le ho thibela sele. ho ata. Mitochondrial complex I, e kentsoeng ka har'a lisele tsa mofets'e ho fihlela litlhoko tsa bona tse ntseng li eketseha tsa matla, e bapala karolo ea bohlokoa ho nts'etsopele ea ho ata ha lisele tsa mofets'e.
Sepheo: OXPHOS