Flibanserin

Lebitso la lik'hemik'hale:

1-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazol-2(3H)-one hydrochloride

SMILES Khouto:

O=C1NC2=CC=CC=C2N1CCN3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3

Khoutu ea InChi:

InChI=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12-26)10-13-27-18- 7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)

InChi Key:

PPRRDFIXUUSXRA-UHFFFAOYSA-N

Keyword:

Flibanserin, 167933-07-5

Sollubility:E qhibiliha ka DMSO

Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).

Tlhaloso:

Flibanserin ke agonist e feletseng ea 5-HT1A receptor (Ki = 1 nM) 'me, ka kamano e tlaase, e le mohanyetsi oa 5-HT2A receptor (Ki = 49 nM) le mohanyetsi kapa agonist e fokolang haholo ea D4 receptor ( Ki = 4–24 nM). Ho sa tsotellehe kamano e kholoanyane ea flibanserin bakeng sa 5-HT1A receptor, le ka mabaka a sa tsejoeng, flibanserin e nka li-receptor tsa 5-HT1A le 5-HT2A ka vivo ka liphesente tse tšoanang. Flibanserin e boetse e na le kamano e tlaase bakeng sa 5-HT2B receptor (Ki = 89.3 nM) le 5-HT2C receptor (Ki = 88.3 nM), eo ka bobeli e itšoarang e le mohanyetsi oa. Flibanserin e khetha ka ho khetheha li-receptor tsa 5-HT1A ka har'a prefrontal cortex, e bonts'a khetho ea libaka, 'me e fumanoe e eketsa maemo a dopamine le norepinephrine le ho fokotsa maemo a serotonin ka har'a rat prefrontal cortex, liketso tse neng li ikemiselitse ho kena lipakeng ka ts'ebetsong ea 5-HT1A. moamoheli.[12] Ka hona, flibanserin e hlalositsoe e le norepinephrine-dopamine disinhibitor (NDDI). Flibanserin e ile ea amoheloa ka August 2015 bakeng sa phekolo ea basali ba pele ho menopausal ba nang le bothata ba ho kopanela liphate (HSDD).

Sepheo: 5HT