E-7046

Lebitso la lik'hemik'hale:

(S) -4-(1-(3-(difluoromethyl)-1-methyl-5-(3-(trifluoromethyl)phenoxy)-1H-pyrazole-4-carboxamido)ethyl)benzoic acid

SMILES Khouto:

O=C(O)C1=CC=C([C@@H](NC(C2=C(OC3=CC=CC(C(F)(F)F)=C3)N(C)N=C2C (F)F)=O)C)C=C1

Khoutu ea InChi:

InChI=1S/C22H18F5N3O4/c1-11(12-6-8-13(9-7-12)21(32)33)28-19(31)16-17(18(23)24)29-30( 2 )20(16)34-15-5-3-4-14(10-15)22(25,26)27/h3-11,18H,1-2H3,(H,28,31)(H,32 ,33)/t11-/m0/s1

InChi Key:

MKLKAQMPKHNQPR-NSHDSACASA-N

Keyword:

E-7046, E7046, E 7046, 1369489-71-3

Sollubility:E qhibiliha ka DMSO

Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).

Tlhaloso:

Moetsong oa tumor oa CT-26, motsoako oa E7046 / RT o baka karabelo ea memori ea anti-tumor ea liphoofolo tse 9. Moetsong oa 4T1, motsoako oa E7046 le RT o boetse o hlahisa ts'ebetso e ntle ea thibelo ea kholo ea tumor ha e bapisoa le kalafo ka 'ngoe feela. Motsoako ona o ntlafatsa bophelo haholo ka ho thibela metastasis ea matšoafo e latelang ea 4T1 [1]. E7046 (150 mg / kg) e thibela kholo ea mefuta e mengata ea lihlahala tsa syngeneic. Thibelo ea pontšo ea EP4 e khothalletsa phapang ea anti-tumor DC mme e liehisa kholo ea tumor ho litoeba. Kalafo ea E7046 e fokotsa kholo kapa esita le ho hana lihlahala tse thehiloeng ho vivo ka mokhoa o itšetlehileng ka lisele tsa myeloid le CD8C T. Ho feta moo, tsamaiso e kopanetsoeng ea E7046 le E7777, protheine ea IL-2-diphtheria toxin fusion e khethang ho bolaea Tregs, ka synergistically e senya marang-rang a myeloid le Treg immunosuppressive, e leng se bakang likarabo tse sebetsang le tse tšoarellang tsa ho itšireletsa mafung ho mefuta ea lihlahala tsa mouse [2] .

Sepheo: EP4