BI-3406
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 0.5g | E teng thepeng e teng ka lebenkeleng | 850 |
| 1g | E teng thepeng e teng ka lebenkeleng | 1450 |
| 5g | E teng thepeng e teng ka lebenkeleng | 6200 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
N-((R)-1-(3-amino-5-(trifluoromethyl)phenyl)ethyl)-7-methoxy-2-methyl-6-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin- 4-amine
SMILES Khouto:
C[C@H](C1=CC(N)=CC(C(F)(F)F)=C1)NC2=C3C(C=C(OC)C(O[C@H]4CCOC4)=C3 )=NC(C)=N2
Khoutu ea InChi:
InChI=1S/C23H25F3N4O3/c1-12(14-6-15(23(24,25)26)8-16(27)7-14)28-22-18-9-21(33-17-4- 5-32-11- 17)20(31-3)10-19(18)29-13(2)30-22/h6-10,12,17H,4-5,11,27H2,1-3H3,(H,28,29 ,30)/t12-,17+/m1/s1
InChi Key:
XVFDNRYZXDHTHT-PXAZEXFGSA-N
Keyword:
BI-3406; BI 3406; BI3406
Sollubility:
Polokelo:
Tlhaloso:
BI-3406 ke e Matla & e Khethang SOS1 :: KRAS Inhibitor (IC50=5 nM), e Bulang Mokhoa o Mocha oa ho Phekola Lihlahala Tse Tsamauoang ke KRAS. BI 3406 ka boikhethelo e tlama ho SOS1 mme e thibela tšebelisano le KRAS, ho sa tsotelehe phetoho ea KRAS. BI 3406 e baka phokotso ea RAS GTP le pERK mme e thibela kholo ea lisele tsa lisele tsa KRAS tse fetotsoeng, tse nang le boholo ba liphetoho tse tloaelehileng tsa KRAS (ke hore G12D, G12V, G13D le tse ling). BI 3406, ha e tsamaisoa ka molomo ho litoeba tse nang le hlahala, e baka lethal dose e itšetlehileng ka tumor static effect e ka fetoloang ho fokotseha ha e kopantsoe le thibelo ea MEK1.
Sepheo: SOS1
