BMS-986165
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 10mg | E teng thepeng e teng ka lebenkeleng | 260 |
| 100mg | E teng thepeng e teng ka lebenkeleng | 530 |
| 1g | E teng thepeng e teng ka lebenkeleng | 1350 |
Lebitso la lik'hemik'hale:
6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3 - carboxamide
SMILES Khouto:
O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C=N4)=C3OC)NC([2H])([2H])[ 2H]
Khoutu ea InChi:
InChI=1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4- 5-12 (17(13)31-3)18-22-10-28(2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)(H2,23) ,24,25,29)/i1D3
InChi Key:
BZZKEPGENYLQSC-FIBGUPNXSA-N
Keyword:
1609392-27-9;CAS:1609392-27-9;CAS:1609392-27-9;BMS-986165; BMS 986165; BMS986165; Deucravacitinib
Sollubility:E qhibiliha ka DMSO
Polokelo:E omme, e lefifi le ho 0 - 4 C bakeng sa nako e khutšoanyane (matsatsi ho isa ho libeke) kapa -20 C bakeng sa nako e telele (likhoeli ho isa ho lilemo).
Tlhaloso:
BMS-986165 ke Allosteric Inhibitor e Matla le e Khethollang ea TYK2. BMS-986165 Blocks Il-12, IL-23 le mofuta oa I Interferon Signaling 'me e fana ka katleho e matla ho Mehlala ea Preclinical ea Mafu a ho ruruha. MS-986165 e tlama ka matla sebakeng sa Tyk2 pseudokinase (Ki = 0.02 nM), 'me e khetha haholo khahlanong le sehlopha sa 265 kinases le pseudokinases. Motsoako o ile oa thibela ka matla IL-23-, IL-12-, le mofuta oa I-interferon-driven cellular signaling and transcriptional responses (IC50 range 2-14 nM).
Sepheo: TYK2
