BAY598 R-isomer
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 50mg | e teng thepeng e teng ka lebenkeleng | Fumana quote |
| 250mg | e teng thepeng e teng ka lebenkeleng | Fumana quote |
| 500mg | e teng thepeng e teng ka lebenkeleng | Fumana quote |
Lebitso la lik'hemik'hale:
(R,E)-N-(1-(N'-cyano-N-(3-(difluoromethoxy)phenyl)carbamimidoyl)-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol- 4-yl) -N-ethyl-2-hydroxyacetamide
SMILES Khouto:
CCN([C@@H]1CN(N=C1C2=CC(Cl)=C(C=C2)Cl)/C(NC3=CC=CC(OC(F)F)=C3)=N/C# N)C(CO)=O
Khoutu ea InChi:
InChI=1S/C22H20Cl2F2N6O3/c1-2-31(19(34)11-33)18-10-32(30-20(18)13-6-7-16(23)17(24)8-13) 22( 28-12-27)29-14-4-3-5-15(9-14)35-21(25)26/h3-9,18,21,33H,2,10-11H2,1H3,(H ,28,29)/t18-/m1/s1
InChi Key:
OTTJIRVZJJGFTK-GOSISDBHSA-N
Keyword:
BAY-598 R-isomer; BAY 598 R-isomer; BAY598 R-isomer
Sollubility:DMSO
Polokelo:
Tlhaloso:
BAY-598 R-isomer ke R-isomer ea BAY589. BAY-598 R-isomer e ka sebelisoa e le motsoako oa litšupiso. BAY-598 ke mokhoa o matla, oa tlholisano oa lik'hemik'hale oa peptide bakeng sa SMYD2. BAY-598 e na le chemotype e ikhethang e amanang le probe ea hajoale ea lik'hemik'hale ea SMYD2 LLY-507. BAY-598 e thibela in vitro methylation ea p53K370 e nang le IC50 = 27 nM 'me e na le khetho e fetang 100 ho feta tse ling tsa histone methyltransferase le lipakane tse ling tseo e seng tsa epigenetic. BAY-598 e thibela methylation ea p53K370 liseleng tse nang le IC50.<1µM. (Ho feta mona, BAY-598 e na le thepa e tsamaellanang le liteko tsa vivo.) Motsoako oa taolo, BAY-369, le ona o entsoe. BAY-369 e thibela in vitro methylation ea p53K370 ka IC50 >70 micromolar.
Sepheo:
