BAY-598

Lebitso la lik'hemik'hale:

(S,E)-N-(1-(N'-cyano-N-(3-(difluoromethoxy)phenyl)carbamimidoyl)-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol- 4-yl) -N-ethyl-2-hydroxyacetamide

SMILES Khouto:

CCN(C(CO)=O)[C@H]1CN(/C(NC2=CC=CC(OC(F)F)=C2)=N/C#N)N=C1C3=CC(Cl)= C(Cl)C=C3

Khoutu ea InChi:

InChI=1S/C22H20Cl2F2N6O3/c1-2-31(19(34)11-33)18-10-32(30-20(18)13-6-7-16(23)17(24)8-13) 22( 28-12-27)29-14-4-3-5-15(9-14)35-21(25)26/h3-9,18,21,33H,2,10-11H2,1H3,(H ,28,29)/t18-/m0/s1

InChi Key:

OTTJIRVZJJGFTK-SFHVURJKSA-N

Keyword:

BAY-598; BAY 598; BAY598

Sollubility:DMSO

Polokelo: 

Tlhaloso:

BAY-598 ke mokhoa o matla, oa tlholisano oa lik'hemik'hale oa peptide bakeng sa SMYD2. BAY-598 e na le chemotype e ikhethang e amanang le probe ea hajoale ea lik'hemik'hale ea SMYD2 LLY-507. BAY-598 e thibela in vitro methylation ea p53K370 e nang le IC50 = 27 nM 'me e na le khetho e fetang 100 ho feta tse ling tsa histone methyltransferase le lipakane tse ling tseo e seng tsa epigenetic. BAY-598 e thibela methylation ea p53K370 liseleng tse nang le IC50.<1µM. (Ho feta mona, BAY-598 e na le thepa e tsamaellanang le liteko tsa vivo.) Motsoako oa taolo, BAY-369, le ona o entsoe. BAY-369 e thibela in vitro methylation ea p53K370 ka IC50 >70 micromolar.

Sepheo: probe ea lik'hemik'hale bakeng sa SMYD2