BAY-850

Lebitso la lik'hemik'hale:

N-((R)-1-(((1s,4S)-4-aminocyclohexyl)amino)-3-(4-cyanophenyl)propan-2-yl)-2-chloro-4-methoxy-5-(5 -(((R)-1-(p-tolyl)ethyl)amino)methyl)furan-2-yl)benzamide

SMILES Khouto:

ClC(C(C(N[C@H])(CC1=CC=C(C#N)C=C1)CN[C@@H]2CC[C@H](N)CC2)=O)=C3 )=CC(OC)=C3C(O4)=CC=C4CN[C@H](C)C5=CC=C(C)C=C5

Khoutu ea InChi:

InChI=1S/C38H44ClN5O3/c1-24-4-10-28(11-5-24)25(2)42-23-32-16-17-3 6(47-32)34-19-33(35(39)20-37(34)46-3)38(45)44-31(18-26-6-8-27(21-4) 0)9-7-26)22-43-30-14-12-29(41)13-15-30/h4-11,16-17,19-20,25,29-31 ,42-43H,12-15,18,22-23,41H2,1-3H3,(H,44,45)/t25-,29-,30+,31-/m1/s1

InChi Key:

BSISGUIVBKDTQO-QIKYYPRYSA-N

Keyword:

BAY-850; BAY850; BAY 850

Sollubility:DMSO

Polokelo: 

Tlhaloso:

"BAY-850 ke probe ea lik'hemik'hale bakeng sa ATAD2A bromodomain e tlosang acetylated H4 peptide ho tloha ATAD2 bromodomain ka IC50 value ea 20 nM (HTRF). Litekanyo tsa MST le BROMOscan li bontša Kd ea 84.9 nM le 120 nM, BAY- ka ho latellana. 850 e bonts'a khetho e ntle ho feta li-bromodomain tse ling kaofela (che e otla ka BROMOscan ka 10 µM) mme e tlosa chromatin ka har'a lisele tse phelang sebakeng sa 1 µM joalo ka ha ho laetsoe ke FRAP Ho qoba litlamorao tse sa tobang tse ka bang teng tsa ≥ 5 µM ha lia khothaletsoa (http:/ /www.thesgc.org/chemical-probes/BAY-850) "

Sepheo: probe ea lik'hemik'hale bakeng sa ATAD2A bromodomain