PRT-060318; PRT318; P142–76
Faahfaahinta Alaabta
Tags Product
| Cabbirka Xidhmada | Helitaanka | Qiimaha (USD) |
| 500mg | In Stock | 900 |
| 1g | In Stock | 1350 |
| Cabiro badan | Hel Xigasho | Hel Xigasho |
Magaca Kiimikada:
2-((1R,2S)-2-aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide
Koodhka dhoola cadeynta:
O=C(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(C)=C3)N
Koodhka InChi:
InChi=1S/C18H24N6O/c1-11-5-4-6-12(9-11)22-17-13(16(20)25)10-21-18(24-17)23-15-8- 3-2-7 -14(15)19/h4-6,9-10,14-15H,2-3,7-8,19H2,1H3,(H2,20,25)(H2,21,22,23,24)/ t14-,15+/m0/s1
Furaha InChi:
NZNTWOVDIXCHHS-LSDHHAIUSA-N
Ereyga muhiimka ah:
PRT-060318,PRT318, P142–76, PRT060318, PRT 060318, PRT318, PRT-318, PRT 318, 1194961-19-7
Xalka:Ku milmay DMSO
Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo)
Sharaxaad:
PRT060318 waa xakameyn awood leh oo la xushay oo ka mid ah beeryarada tyrosine kinase (Syk; IC50 = 4 nM) 270 kinases. PRT060318 waxay joojisaa isku-darka miyir-beelka-ku-soo-baxa ee balaasmaha qani ku ah platelet-ka (IC50 = 2.5 μM) ee vitro waxayna ka hortagtaa xinjirowga qaabka jiirka transgenic ee trombocytopenia heparin-induced. Waxay keentaa lymphocytic leukemia (CLL) apoptosis unugyada B waxayna joojisaa dheecaanka chemokines CCL3, CCL4, iyo CXCL13.3 PRT060318 waxay sidoo kale joojisaa chemotaxis unug CLL B iyo pseudoemperipolesis.
Ujeedka: Syk
