BAY 61-3606 2HCl

Magaca Kiimikada:

2-[[7- (3,4-Dimethoxyphenyl) imidazo [1,2-c] pyrimidin-5-yl] amino] -3-pyridinecarboxamide dihydrochloride

Koodhka dhoola cadeynta:

O=C(N)C1=C(NC2=NC(C3=CC=C(OC)C(OC)=C3=CC4=NC=CN24)N=CC=C1.[H]Cl.[H] Cl

Koodhka InChi:

InChi=1S/C20H18N6O3.2ClH/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24- 14)25-19-13 (18(21)27)4-3-7-23-19;/h3-11H,1-2H3,(H2,21,27)(H,23,24,25) ;2*1H

Furaha InChi:

SPMFEULFGGPQLN-UHFFFAOYSA-N

Ereyga muhiimka ah:

BAY 61-3606, 648903-57-5, BAY 613606, BAY-613606, BAY-61-3606

Xalka:Ku milmay DMSO

Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo)

Sharaxaad:

BAY 61-3606 waa mid awood leh (Ki = 7.5 nM) iyo xakameynta xulashada Syk kinase. BAY 61-3606 waxay joojisay kaliya hoos u dhigista (qiyamka IC50 ee u dhexeeya 5 iyo 46 nM) laakiin sidoo kale dhexdhexaadiyaha dufanka iyo cytokine synthesis ee unugyada mastarada. BAY 61-3606 waxay ahayd mid aad waxtar u leh basophils laga helay maadooyinka caafimaadka leh ee bini'aadamka (IC50 = 10 nM) waxayna u muuqataa inay ugu yaraan awood u leedahay basophils laga helay maadooyinka atopic (serum sare IgE) (IC50 = 8.1 nM). Dhaqdhaqaaqa soo dhaweynta unugyada B iyo soo-dhoweeyayaasha qaybta Fc ee calaamadda IgG ee eosinophils iyo monocytes ayaa sidoo kale si xoog leh loo xakameeyay BAY 61-3606.

Ujeedka: Syk