GDC-0077

Magaca Kiimikada:

(S)-2-(2-((S)-4-(difluoromethyl) -2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f] imidazo[1,2-d] [1,4] ]oxazepin-9-yl)amino)propanamide

Koodhka dhoola cadeynta:

C[C@@H](C(N)=O)NC1=CC=C(C2=NC(N3[C@H](C(F)F)COC3=O)=CN2CCO4)C4=C1

Koodhka InChi:

InChi=1S/C18H19F2N5O4/c1-9(16(21)26)22-10-2-3-11-13(6-10)28-5-4-24-7-14(23-17(11) 24)2 5-12 (15 (19)20)8-29-18 (25)27/h2-3,6-7,9,12,15,22H,4-5,8H2,1H3,(H2,21,26 )/t9-,12-/m0/s1

Furaha InChi:

SGEUNORSOZVTOL-CABZTGNLSA-N

Ereyga muhiimka ah:

GDC-0077, GDC0077, GDC 0077, 2060571-02-8

Xalka:Ku milmay DMSO

Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo).

Sharaxaad:

GDC-0077 waa mid afka laga heli karo oo la xushay inhibitor PI3K (IC50 = 0.038 + 0.003 nM) oo leh> 300-laab ka door bida qaybaha kale ee I PI3K. GDC-0077 waxa ay fulisaa hawlaheeda iyada oo ku xidhan goobta xidhitaanka ATP ee PI3K, taas oo ka hortagaysa fosforyaalka PIP2 ilaa PIP3.

Hadafka: PI3K