AMG-510

Magaca Kiimikada:

4-((S) -4-acryloyl-2-methylpiperazin-1-yl) -6-fluoro-7- (2-fluoro-6-hydroxyphenyl) -1- (2-isopropyl-4-methylpyridin-3-yl) )pyrido[2,3-d]pyrimidin-2(1H) -hal

Koodhka dhoola cadeynta:

O=C(C=C)N1C[C@H](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C (C5=C(O)C=CC=C5F)=N4=O)CC1

Koodhka InChi:

InChi=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8- 7-9-22 (24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6- 11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1

Furaha InChi:

NXQKSXLFSAEQCZ-SFHVURJKSA-N

Ereyga muhiimka ah:

AMG-510; AMG 510; AMG510

Xalka: 

Kaydinta: 

Sharaxaad:

AMG-510 waa ka hortag awood leh oo KRAS G12C. AMG-510 waxay si xushmad leh u bartilmaameedsanaysaa mutant-ga KRAS p.G12C, mid ka mid ah DNA, RNA ama heerka borotiinka, waxayna ka hortagtaa, iyada oo loo marayo hab aan weli la caddayn, muujinta iyo/ama unugyada burooyinka ee calaamadinta KRAS p.G12C mutant. Tani waxay joojin kartaa koritaanka KRAS p.G12C-muujinta unugyada burooyinka

Ujeedka: KRAS