AZD8186

Magaca Kiimikada:

(R) -8-(1-(3,5-difluorophenyl)amino) ethyl) -N, N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide

Koodhka dhoola cadeynta:

O=C(N(C)C)C1=CC([C@@H](C)NC2=CC(F)=CC(F)=C2)=C3C(C(C=C(O3)N4CCOCC4) =O)=C1

Koodhka InChi:

InChi=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3)9-20- 21 (30) 13-22 (33-23 (19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3/t14-/m1/s1

Furaha InChi:

LMJFJIDLEAWOQJ-CQSZACIVSA-N

Ereyga muhiimka ah:

AZD8186, AZD-8186, AZD 8186, 1627494-13-6

Xalka:Ku milmay DMSO

Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo)

Sharaxaad:

AZD8186 waa iyo horjoogaha beta isoform of phosphoinotide-3 kinase (PI3K), oo leh firfircoonida antineoplastic ee suurtogalka ah. Marka la maamulo, PI3Kbeta inhibitor AZD8186 waxay si xushmad leh u joojisaa dhaqdhaqaaqa PI3Kbeta ee dariiqa calaamadaynta PI3K/Akt/mTOR, taasoo keeni karta hoos u dhac ku yimaada unugyada burooyinka. Waxa kale oo ay keentaa dhimashada unugyada ee PI3K-muujinta unugyada kansarka. Iyada oo si gaar ah loo beegsanayo heerka I PI3K beta, wakiilkani waxa laga yaabaa inuu ka waxtar badan yahay oo uu ka sun yar yahay ka hortagga PI3K. Calaamadaynta dhexdhexaadinta ee PI3K ayaa badanaa lagu habeeyaa unugyada kansarka waxayna gacan ka geysataa korodhka korriinka unugyada burooyinka, badbaadada, iyo caabbinta buro ee noocyo kala duwan oo ah wakiilada antineoplastic. AZD8186 hadda waxay ku hoos jirtaa tijaabada caafimaadka Wajiga I.

Hadafka: PI3K