Quizartinib; AC-010220; AC-220
Faahfaahinta Alaabta
Tags Product
| Cabbirka Xidhmada | Helitaanka | Qiimaha (USD) |
| 5g | In Stock | 1000 |
| 10g | In Stock | 1500 |
| Cabiro badan | Hel Xigasho | Hel Xigasho |
Magaca Kiimikada:
N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl phenyl}urea
Koodhka dhoola cadeynta:
O=C(NC1=CC=C(C2=CN3C(SC4=CC(OCCN5CCOCC5)=CC=C34)=N2)C=C1)NC6=NOC(C(C)(C)C)=C6
Koodhka InChi:
InChi=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22- 18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4- 9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)
Furaha InChi:
CVWXJKQAOSCOAB-UHFFFAOYSA-N
Ereyga muhiimka ah:
Quizartinib, AC-010220, AC010220, AC 010220, AC-220, AC220, AC 220, 950769-58-1
Xalka:Ku milmay DMSO
Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo)
Sharaxaad:
Quizartinib waa xannibaadaha FMS ee la xidhiidha tyrosine kinase 3 (FLT3; Kd = 1.6 nM) waxayna muujinaysaa xulashada sare ee FLT3 marka lagu tijaabiyo guddi ka mid ah 227 kinase dheeraad ah. Waxay xakameysaa faafinta xariiqda unugyada leukemia ee bini'aadamka MV4-11, kaas oo xajinaya isbeddelka homozygous FLT3-ITD, oo leh IC50 qiimaha 0.56 nM.1 1 mg / kg / maalintii, quizartinib ayaa la muujiyay in ay kordhiso badbaadada jiirka qaabka FLT3-ITD myeloid leukemia ba'an iyo in la cirib tiro burooyinka ku jira qaabka xenograft jiirka FLT3 ku tiirsan ee 10 mg/kg.
Ujeedka: FLT3
