S-600918,Sivopixant

S-600918,Sivopixant
  • Zita:S-600918,Sivopixant
  • Catalog Nhamba:CPD109617
  • Nhamba yeCAS:2414285-40-6
  • Molecular Weight:507.93
  • Chemical Formula:C25 H22 Cl N5 O5
  • Kutsvakurudza kwesayenzi chete, kwete kuvarwere.

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    Chemical Name:

    (2S)-3-[(4E)-3-[(4-chlorophenyl)methyl]-2,6-dioxo-4-({4-[(pyridin-2-yl)oxy]phenyl}imino)-1 ,3,5-triazinan-1-yl] -2-methylpropanoic acid

    SMILES Kodhi:

    O=C(O)[C@@H](C)CN1C(N(CC2=CC=C(Cl)C=C2)/C(NC1=O)=N/C3=CC=C(OC4=NC =CC=C4)C=C3)=O

    InChi Code:

    InChI=1S/C25H22ClN5O5/c1-16(22(32)33)14-31-24(34)29-23(30(25(31)35)15-17-5-7-18(26)8- 6-17)28-1 9-9-11-20(12-10-19)36-21-4-2-3-13-27-21/h2-13,16H,14-15H2,1H3,(H,32,33)( H,28,29,34)/t16-/m0/s1

    InChi Key:

    SKZQFKBIJUXXCG-INIZCTEOSA-N

    Keyword:

    2414285-40-6; CAS:2414285-40-6; CAS:2414285-40-6; Sivopixant; S-600918; S 600918; S600918

    Solubility:Soluble muDMSO

    Kuchengeta:Yakaoma, yakasviba uye pa 0 - 4 C kwenguva pfupi (mazuva kusvika kumavhiki) kana -20 C kwenguva refu (mwedzi kusvika kumakore)

    Tsanangudzo:

    Sivopixant, inozivikanwawo seS-600918, inosarudza P2X3 receptor antagonist (P2X3 IC50, 4.2 nM; P2X2 / 3 IC50, 1100 nM). Sivopixant yakaratidza yakasimba analgesic effect mu rat partial sciatic nerve ligation model (Seltzer model) yeallodynia (ED50, 0.4 mg / kg).

    Chinangwa: Sarudza P2X3 receptor antagonist




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