SOS1

CAT #	Product Name	Tsanangudzo
CPD10000	BI-3406	BI-3406 ine Simba & Inosarudza SOS1 :: KRAS Inhibitor (IC50 = 5 nM), iyo Inovhura Nzira Itsva yeKurapa KRAS-inotyairwa Tumours. BI 3406 inosarudza inosunga kuSOS1 uye inovhara kupindirana neKRAS, zvisinei neKRAS mutation. BI 3406 inokonzeresa RAS GTP uye kuderedzwa kweperK uye inhibits kukura kwesero kweKRAS mutated cell mitsara, inotakura yakawanda yeakajairika KRAS mutations (kureva G12D, G12V, G13D nemamwe). BI 3406, kana inopihwa nemuromo kune bundu rinotakura mbeva, inokonzera dose inotsamira bundu static effect iyo inogona kushandurwa kuita regressions kana yasanganiswa ne MEK1 inhibition.
CPD2807	BAY-293	BAY-293 ine simba SOS1 inhibitor inovhara RAS activation kuburikidza nekukanganisa kweRAS-SOS1 kupindirana. BAY-293) inodzivirira kudyidzana kweKRAS-SOS1 neIC50 ye21 nM uye ikemikari yakakosha yekuferefeta kweramangwana.