| CPD10000 | BI-3406 | BI-3406 ine Simba & Inosarudza SOS1 :: KRAS Inhibitor (IC50 = 5 nM), iyo Inovhura Nzira Itsva yeKurapa KRAS-inotyairwa Tumours. BI 3406 inosarudza inosunga kuSOS1 uye inovhara kupindirana neKRAS, zvisinei neKRAS mutation. BI 3406 inokonzeresa RAS GTP uye kuderedzwa kweperK uye inhibits kukura kwesero kweKRAS mutated cell mitsara, inotakura yakawanda yeakajairika KRAS mutations (kureva G12D, G12V, G13D nemamwe). BI 3406, kana inopihwa nemuromo kune bundu rinotakura mbeva, inokonzera dose inotsamira bundu static effect iyo inogona kushandurwa kuita regressions kana yasanganiswa ne MEK1 inhibition. |
