| CAT # | Product Name | Tsanangudzo |
| CPD100608 | ASK1-Inhibitor-10 | ASK1 Inhibitor 10 is an olly bioavailable inhibitor yeapoptosis signal-regulating kinase 1 (ASK1). Inosarudza ASK1 pamusoro peASK2 uyewo MEKK1, TAK-1, IKKβ, ERK1, JNK1, p38α, GSK3β, PKCθ, uye B-RAF. Inodzivisa kuwedzera kwe streptozotocin-induced muJNK uye p38 phosphorylation mu INS-1 pancreatic β masero muhutano-hunoenderana. |
| CPD100607 | K811 | K811 inonzi ASK1-specific inhibitor inorebesa kurarama mumhando yembeva yeamyotrophic lateral sclerosis. K811 yakanyatso dzivirira kupararira kwesero mumitsetse yemasero ane yakakwira ASK1 kutaura uye muHER2-overexpressing GC masero. Kurapa neK811 kwakaderedzwa hukuru hwemamota exenograft nekudzikisira mamaki ekuwedzera. |
| CPD100606 | K812 | K812 inonzi ASK1-specific inhibitor yakawanikwa kuti irebese kurarama mumhando yembeva yeamyotrophic lateral sclerosis. |
| CPD100605 | MSC-2032964A | MSC 2032964A ine simba uye inosarudza ASK1 inhibitor (IC50 = 93 nM). Iyo inovhara LPS-induced ASK1 uye p38 phosphorylation mune yakasimwa mbeva astrocytes uye inodzvanya neuroinflammation mune mbeva EAE modhi. MSC 2032964A inowanikwa nemuromo uye inopinda muuropi. |
| CPD100604 | Selonsertib | Selonsertib, inozivikanwawo se GS-4997, inonzi orally bioavailable inhibitor yeapoptosis signal-regulating kinase 1 (ASK1), ine zvinogona anti-inflammatory, antineoplastic uye anti-fibrotic zviitiko. GS-4997 inotarisa uye inosungira kune catalytic kinase domain ye ASK1 nenzira yeATP-yemakwikwi, nokudaro ichidzivirira phosphorylation uye activation. GS-4997 inodzivirira kugadzirwa kweanopisa cytokines, pasi-inogadzirisa kutaura kwemajini anobatanidzwa mufibrosis, inodzvinyirira yakawandisa apoptosis uye inhibits kupararira kwesero. |
