| CAT # | Product Name | Tsanangudzo |
| CPD100603 | MDK36122 | MDK36122, inozivikanwawo seH-PGDS Inhibitor I, iProstaglandin D Synthase (hematopoietic-type) Inhibitor. MDK36122 haina kodhi zita, uye ine CAS#1033836-12-2. Yekupedzisira 5-manhamba yakashandiswa pazita rekutaura kuri nyore. MDK36122 inovhara HPGDS (IC50s = 0.7 uye 32 nM mune enzyme uye cellular assays, zvichiteerana) nekuita kushoma kunopesana nema enzymes evanhu L-PGDS, mPGES, COX-1, COX-2, uye 5-LOX. |
| CPD100602 | Tepoxalin | Tepoxalin, inozivikanwawo seORF-20485; RWJ-20485; inonzi 5-lipoxygenase inhibitor inogona kurapa asthma, osteoarthritis (OA). Tepoxalin ine mu vivo inhibitory basa rinopesana neCOX-1, COX-2, uye 5-LOX mumbwa pane ikozvino yakagamuchirwa inokurudzirwa dosage.Tepoxalin inhibits kuzvimba uye microvascular dysfunction inokonzerwa neabdominal irradiation mumakonzo. Tepoxalin inowedzera basa re antioxidant, pyrrolidine dithiocarbamate, mukuderedza tumor necrosis factor alpha-induced apoptosis muWEHI 164 masero. |
| CPD100601 | Tenidap | Tenidap, inozivikanwawo seCP-66248, ndeye COX/5-LOX inhibitor uye cytokine-modulating anti-inflammatory drug candidate yakanga iri pasi pekuvandudzwa naPfizer seanovimbisa kurapa rheumatoid arthritis, asi Pfizer akamisa budiriro mushure mekunge mvumo yekushambadzira yarambwa. neFDA muna 1996 nekuda kwechiropa uye chepfu yeitsvo, iyo yainzi yakakonzerwa nematabolites emushonga ane thiophene moiety yakakonzera kukuvadzwa kweiyo oxidative. |
| CPD100600 | PF-4191834 | PF-4191834 ibhuku, rine simba uye rinosarudza risina redox 5-lipoxygenase inhibitor inoshanda mukuzvimba uye kurwadziwa. PF-4191834 inoratidza yakanaka potency mune enzyme- uye maseru-based assays, pamwe neiyo rat modhi yekuzvimba kwakanyanya. Enzyme assay mhedzisiro inoratidza kuti PF-4191834 ine simba 5-LOX inhibitor, ine IC(50) = 229 +/- 20 nM. Uyezve, yakaratidza inenge 300-fold selectivity ye5-LOX pamusoro pe12-LOX uye 15-LOX uye hairatidzi basa kune cyclooxygenase enzymes. Mukuwedzera, PF-4191834 inhibits 5-LOX mumasero eropa evanhu, ine IC (80) = 370 +/- 20 nM. |
| CPD100599 | MK-886 | MK-886, inozivikanwawo seL 663536, inopikisa leukotriene. Inogona kuita izvi nekuvhara 5-lipoxygenase activating protein (FLAP), nokudaro inhibiting 5-lipoxygenase (5-LOX), uye inogona kubatsira mukurapa atherosclerosis. MK-886 inhibits cyclooxygenase-1 basa uye inodzvinyirira platelet aggregation. MK-886 induces shanduko mu cell cycle uye inowedzera apoptosis mushure me photodynamic therapy ne hypericin. MK-886 inowedzera tumor necrosis factor-alpha-induced differentiation uye apoptosis. |
| CPD100598 | L-691816 | L 691816 inhibitor ine simba yeiyo 5-LO maitiro ese ari mu vitro uye mune akasiyana emhando dze vivo. |
| CPD100597 | CMI-977 | CMI-977, inozivikanwawo seLPD-977 uye MLN-977, ine simba 5-lipoxygenase inhibitor inopindira mukugadzirwa kweleukotrienes uye parizvino iri kugadzirwa kuti irapwe asthma isingaperi. CMI-977 inhibits iyo 5-lipoxygenase (5-LO) masero ekuputira nzira yekuvhara chizvarwa che leukotrienes, iyo inoita basa rinokosha mukukonzera bronchial asthma. |
| CPD100596 | CJ-13610 | CJ-13610 inonzi orally active inhibitor ye5-lipoxygenase (5-LO) . CJ-13610 inhibits biosynthesis ye leukotriene B4 uye inogadzirisa IL-6 mRNA kutaura mu macrophages. Inoshanda mune preclinical mhando dzemarwadzo. |
| CPD100595 | BRP-7 | BRP-7 ndeye 5-LO activating protein (FLAP) inhibitor. |
