| CAT # | Product Name | Tsanangudzo |
| CPD3233 | AZD-3409 | AZD-3409 ine simba prenyl transferase inhibitor. AZD-3409 yakaratidza yakakwirira potency kupfuura lonafarnib. Izvo zvinoreva IC(50) ye cytotoxicity yeAZD3409 yaive 510 muMEF maseru, 10,600 muA549 masero uye 6,170 muMCF7 masero, zvichiteerana. Mumasero aya, IC(50) yeFTase chiitiko cheAZD3409 chakabva pa3.0 kusvika pa14.2 nM uye yelonafarnib kubva pa0.26 kusvika 31.3 nM. AZD3409 inhibits farnesylation kusvika pamwero wepamusoro pane geranylgeranylation. Zvese inhibition yefarnesylation uye geranylgeranylation haigone kuve yakabatana neiyo antiproliferative basa remushonga. AZD3409 inogona kunge ichishanda mu gefitinib-resistant breast carcinoma. |
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