GDC-0326

Chemical Name:

(S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4 ]oxazepin-9-yl)oxy)propanamide

SMILES Kodhi:

C[C@H](OC1=CC=C2C3=NC(C4=NC=NN4C(C)C)=CN3CCOC2=C1)C(N)=O

InChi Code:

InChI=1S/C19H22N6O3/c1-11(2)25-19(21-10-22-25)15-9-24-6-7-27-16-8-13(28-12(3)17( 20)26)4-5-14(16)18(24)23-15/h4-5,8-12H,6-7H2,1-3H3,(H2,20,26)/t12-/m0/s1

InChi Key:

SIKYDKLGPWRPMZ-LBPRGKRZSA-N

Keyword:

GDC-0326, GDC0326, GDC 0326, 1282514-88-8

Solubility:Soluble muDMSO

Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi)

Tsanangudzo:

GDC-0326 ine simba uye inosarudza inhibitor ye α-Isoform yePhosphoinositide 3-Kinase (PI3Kalpha inhibitor). GDC-0326 inosvika padanho repamusoro rekusarudza pane mamwe kinase. GDC-0326 ine low plasma CL mumunhu. Mukati mePI3 kinase mhuri, mune ina kirasi I PI3K isoforms (α, β, δ, uye γ). Pakati peaya isoforms, PI3Kα ndiyo inonyanya kubatanidzwa negomarara.

Chinangwa: PI3K