BMS-986195

Chemical Name:

(S)-4-(3-(asi-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide

SMILES Kodhi:

FC1=C(N2CCC[C@H](NC(C#CC)=O)C2)C3=C(NC(C)=C3C)C(C(N)=O)=C1

InChi Code:

InChI=1S/C20H23FN4O2/c1-4-6-16(26)24-13-7-5-8-25(10-13)19-15(21)9-14(20(22)27)18- 17(19)11(2)12(3)23-18/h9,13,23H,5,7-8,10H2,1-3H3,(H2,22,27)(H,24,26)/t13 -/m0/s1

InChi Key:

VJPPLCNBDLZIFG-ZDUSSCGKSA-N

Keyword:

BMS-986195, BMS 986195, BMS986195, 1912445-55-6

Solubility:Soluble muDMSO

Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi).

Tsanangudzo:

BMS-986195 inhibitor ine simba, yakabatana, isingachinjiki yeBruton's tyrosine kinase (BTK), inhengo yemhuri yeTec yevasiri-receptor tyrosine kinases yakakosha mune antigen-inotsamira B-cell kusaina uye basa. BMS-986195 inodarika 5000-inosarudza BTK pamusoro pese kinase kunze kweTec mhuri, uye kusarudza kunotangira pa9- kusvika 1010-fold mukati meTec mhuri. BMS-986195 inactivated BTK muropa revanhu rose nekukasira kwekuita (3.5×10-4 nM-1·min-1) uye zvine simba inhibited antigen-dependent interleukin-6 kugadzirwa, CD86 kutaura uye kuwanda muB masero (IC50<1 nM) pasina mhedzisiro pane antigen-yakazvimirira matanho mumasero mamwechete.

Chinangwa: BTK