BMS-986165

Chemical Name:

6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3 -carboxamide

SMILES Kodhi:

O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C=N4)=C3OC)NC([2H])([2H])[ 2H]

InChi Code:

InChI=1S/C20H22N8O3/c1-21-20(30)16-14(9-15(25-26-16)24-19(29)11-7-8-11)23-13-6-4- 5-12 (17(13)31-3)18-22-10-28(2)27-18/h4-6,9-11H,7-8H2,1-3H3,(H,21,30)(H2,23) ,24,25,29)/i1D3

InChi Key:

BZZKEPGENYLQSC-FIBGUPNXSA-N

Keyword:

1609392-27-9;CAS:1609392-27-9;CAS：1609392-27-9;BMS-986165; BMS 986165; BMS986165; Deucravacitinib

Solubility:Soluble muDMSO

Kuchengeta:Dry, rima uye pa 0 - 4 C kwenguva pfupi (mazuva kusvika mavhiki) kana -20 C kwenguva refu (mwedzi kusvika kumakore).

Tsanangudzo:

BMS-986165 is Highly Potent and Selective Allosteric Inhibitor yeTYK2. BMS-986165 Blocks Il-12, IL-23 uye mhando I Interferon Signaling uye Inopa Kushanda Kwakasimba mu Preclinical Models yeInflammatory Bowel Disease. MS-986165 inosunga zvine simba kuTyk2 pseudokinase domain (Ki = 0.02 nM), uye inosarudza zvakanyanya kutarisana nepaneru ye265 kinases uye pseudokinases. Mushonga wacho wakanyatso kuvharidzirwa IL-23-, IL-12-, uye Type I interferon-driven cellular signing uye transcriptional responses (IC50 range 2-14 nM).

Chinangwa: TYK2