BMS-955176

Chemical Name:

4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-((2-(1,1-dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a pentamethyl-1 -(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro -1H-cyclopenta[a]chrysen-9-yl)benzoic acid

SMILES Kodhi:

O=C(O)C1=CC=C(C2=CC[C@@]3(C)[C@@](C2(C)C)([H])CC[C@@]4(C) )[C@]5(C)CC[C@](C C[C@H]6C(C)=C)(NCCN(CC7)CCS7(=O)=O)[C@@]6([H])[C@]]5([H])CC[ C@]34[H])C=C1

InChi Code:

InChI=1S/C42H62N2O4S/c1-28(2)31-14-19-42(43-22-23-44-24-26-49(47,48)2 7-25-44)21-20-40(6)33(36(31)42)12-13-35-39(5)17-15-32(29-8-10-30(11-9) -29)37(45)46)38(3,4)34(39)16-18-41(35,40)7/h8-11,15,31,33-36,43H,1,12 -14,16-27H2,2-7H3,(H,45,46)/t31-,33+,34-,35+,36+,39-,40+,41+,42-/m0/s1

InChi Key:

XDMUFNNPLXHNKA-ZTESCHFWSA-N

Keyword:

GSK3532795, GSK-3532795, GSK 3532795, BMS-955176, BMS 955176, BMS955176

Solubility: 

Kuchengeta: 

Tsanangudzo:

GSK3532795, inozivikanwawo seBMS-955176, ine simba, inoshanda nemuromo, yechipiri-chizvarwa HIV-1 maturation inhibitor (MI) iyo yakafambira mberi kuburikidza nechikamu IIb kiriniki miedzo. GSK3532795 inosanganisa kufukidza kwakafara kwepolymorphic virus (EC50<15 nM yakatarisana nepanera remapolymorphisms anomiririra 96.5% HIV-1 subtype B virus) ine yakanaka pharmacokinetic profile mu preclinical marudzi.

Chinangwa: HIV-1 maturation inhibitor (MI)