BI-2852
Product Detail
Product Tags
| Pack Saizi | Kuwanikwa | Mutengo (USD) |
Chemical Name:
(S)-5-hydroxy-3-(2-((((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methyl)amino)methyl) -1H-indol-3-yl)isoindolin-1-imwe
SMILES Kodhi:
OC(C=C1)=CC([C@@H](C2=C(CNCC3=CC4=C(C=CN4CC5=CN(C)C=N5)C=C3)NC6=CC=CC=C62) N7)=C1C7=O
InChi Code:
InChI=1S/C31H28N6O2/c1-36-16-21(33-18-36)17-37-11-10-20-7-6-19(12-28(20)37)14-32-15- 27-29(24-4-2-3-5-26(2 4)34-27)30-25-13-22(38)8-9-23(25)31(39)35-30/h2-13,16,18,30,32,34,38H,14- 15,17H2,1H3,(H,35,39)/t30-/m0/s1
InChi Key:
JYEQLXOWWLNVDX-PMERELPUSA-N
Keyword:
Solubility:
Kuchengeta:
Tsanangudzo:
BI-2852 inhibitor ine simba yeKRAS inosunga ne nanomolar affinity muhomwe, kusvika parizvino inoonekwa se "isingachinjiki," pakati pe switch I uye II paRAS. BI-2852 yakasiyana nemakanika kubva kune covalent KRASG12C inhibitors nekuti inosungira kune imwe homwe iripo mune ese ari maviri anoshanda uye asingashande mafomu eKRAS. BI-2852 inovhara GEF, GAP, uye kupindirana kwekuita neKRAS, zvichikonzera kudzivirirwa kwechiratidzo chepasi uye antiproliferative mhedzisiro muKRAS mutant masero.
Chinangwa: KRAS
