Sildenafil Citrate
Fa'amatalaga Oloa
Faailoga o oloa
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Igoa vaila'au:
5-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin- 7-tasi 2-hydroxypropane-1,2,3-tricarboxylate
SMILES Code:
"CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)CC(C(=O)O )C(CC(=O)O)(C(=O)O)O "
InChi Code:
InChI=1S/C22H30N6O4S.C6H8O7/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9- 18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28;7-3(8)1-6(13,5(11)12) 2-4(9)10/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29);13H,1-2H2,(H,7,8)( H,9,10)(H,11,12)
InChi Key:
DEIYFTQMQPDXOT-UHFFFAOYSA-N
upu autu:
Sildenafil Citrate; UK 92480-10; UK-92,480-10; Revatio; VIAGRA; 171599-83-0; CAS: 171599-83-0; CAS: 171599-83-0
Solubility:Solu i le DMSO
Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), po'o le -20°C mo taimi uumi (masina)
Fa'amatalaga:
Sildenafil, Citrate o se ituaiga citrate o Sildenafil. O le Sildenafil o se fa'amalosaga filifilia o le PDE5 (ituaiga 5 cGMP phosphodiesterase) lea e faʻamalosia ai le hydrolysis o le 3',5'-cyclic guanosine monophosphate (cGMP). I le avea ai o se inhibitor PDE5, ua lipotia mai le Sildenafil e faʻaleleia le neuro-, synapto- ma le angiogenesis i faʻataʻitaʻiga o isumu o le stroke ma ua lipotia mai foi o se vasodilator vaivai. Ua fa'aalia fo'i le Sildenafil e puipuia ai le fa'atupuina o le ma'i o le intestinal indomethacin e ala i se masini fa'alagolago i le NO/cGMP.
Sini: PDE5