SB-204990

Igoa vaila'au:

trans-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid

SMILES Code:

O=C(O)C[C@@]1(O)C(O[C@H](CCCCCCC2=CC=C(Cl)C=C2Cl)C1)=O

InChi Code:

InChI=1S/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,1) 1-16(21)22)17(23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18-/m1/s1

InChi Key:

YTRNLFYTHYWDAU-RDTXWAMCSA-N

upu autu:

SB-204990, SB 204990, SB204990

Solubility: 

Teuina: 

Fa'amatalaga:

SB-204990 o le prodrug o le malosi ATP citrate-lyase inhibitor SB-201076. SB-204990, pe a tuʻuina atu tautala i isumu, na faʻafefe i totonu o le faʻaogaina o le tino, o vailaʻau talafeagai o le SB-201076 na toe maua i le ate. SB-204990 (25 mg/kg i le aso) na faʻaititia ai foi le maualuga o le cholesterol plasma (e oʻo atu i le 23%) ma le maualuga o le triglyceride (e oʻo atu i le 38%) i le taifau, e sili atu le faʻaitiitia o le lipoprotein maualalo pe a faʻatusatusa i le maualuga-density lipoprotein cholesterol. tulaga. O le SB-204990 ose enzyme taua i le puleaina o le sapalai o mea'ai mo le lipid synthesis de novo ma se fa'amoemoega ole enzyme mo le hypolipidaemic intervention.

Sini: