S-600918，Sivopixant

Igoa vaila'au:

(2S)-3-[(4E)-3-[(4-chlorophenyl)methyl]-2,6-dioxo-4-({4-[(pyridin-2-yl)oxy]phenyl}imino)-1 ,3,5-triazinan-1-yl]-2-methylpropanoic acid

SMILES Code:

O=C(O)[C@@H](C)CN1C(N(CC2=CC=C(Cl)C=C2)/C(NC1=O)=N/C3=CC=C(OC4=NC =CC=C4)C=C3)=O

InChi Code:

InChI=1S/C25H22ClN5O5/c1-16(22(32)33)14-31-24(34)29-23(30(25(31)35)15-17-5-7-18(26)8- 6-17)28-1 9-9-11-20(12-10-19)36-21-4-2-3-13-27-21/h2-13,16H,14-15H2,1H3,(H,32,33)( H,28,29,34)/t16-/m0/s1

InChi Key:

SKZQFKBIJUXXCG-INIZCTEOSA-N

upu autu:

2414285-40-6; CAS:2414285-40-6; CAS:2414285-40-6; Sivopixant; S-600918; S 600918; S600918

Solubility:Solu i le DMSO

Teuina:Mago, pogisa ma ile 0 - 4 C mo taimi pupuu (aso i vaiaso) po'o le -20 C mo taimi uumi (masina i tausaga)

Fa'amatalaga:

Sivopixant, lea e taʻua foi o le S-600918, o se P2X3 faʻafeiloaʻi faʻafefe (P2X3 IC50, 4.2 nM; P2X2/3 IC50, 1100 nM). Na faʻaalia e le Sivopixant se malosi faʻamaʻi faʻamalosi i le faʻataʻitaʻiga o le ligation nerve rat sciatic (Seltzer model) o allodynia (ED50, 0.4 mg / kg).

Manulauti: Filifiliga P2X3 fa'afeagai tali