Resmetirom

Igoa vaila'au:

Resmetirom

SMILES Code:

N#CC1=NN(C2=CC(Cl)=C(OC(C=C3C(C)C)=NNC3=O)C(Cl)=C2)C(NC1=O)=O

InChi Code:

InChI=1S/C17H12Cl2N6O4/c1-7(2)9-5-13(22-23-15(9)26)29-14-10(18)3-8(4-11(14)19)25- 17(28)21-16(27)12(6-20)24-25/h3-5,7H,1-2H3,(H,23,26)(H,21,27,28)

InChi Key:

FDBYIYFVSAHJLY-UHFFFAOYSA-N

upu autu:

MGL-3196; MGL 3196; VIA 3196; VIA-3196; Resmetirom

Solubility:Solu i le DMSO, ae le o le vai

Teuina:0 - 4 C mo taimi pupuu (aso i vaiaso), poʻo -20 C mo taimi uumi (masina)

Fa'amatalaga:

Resmetirom, e lauiloa foi o le MGL-3196, o se malosi ma sili ona filifilia thyroid hormone receptor β agonist i suʻesuʻega faʻapitoa mo togafitiga o le dyslipidemia. O aʻafiaga aoga o le thyroid hormone (TH) i luga o le lipid e mafua ona o lona gaioiga i le thyroid hormone receptor β (THR-β) i le ate, ae o aʻafiaga leaga, e aofia ai aʻafiaga o le fatu, e faʻatalanoaina e le thyroid hormone receptor α (THR). -a).

Sini: THR-β