| PUSI # | Igoa Oloa | Fa'amatalaga |
| CPD100608 | ASK1-Inhibitor-10 | ASK1 Inhibitor 10 o se fa'agata fa'aola fa'aolaola ole apoptosis signal-regulating kinase 1 (ASK1). E filifilia mo ASK1 i luga ole ASK2 faʻapea foi MEKK1, TAK-1, IKKβ, ERK1, JNK1, p38α, GSK3β, PKCθ, ma B-RAF. E taofia ai le faateleina o le streptozotocin i le JNK ma le p38 phosphorylation i le INS-1 pancreatic β sela i se tulaga faʻalagolago. |
| CPD100607 | K811 | K811 ose ASK1-specific inhibitor e faʻaumiina le ola i se faʻataʻitaʻiga o le isumu o le amyotrophic lateral sclerosis. O le K811 na puipuia lelei le fa'atuputeleina o sela i laina sela e maualuga le fa'aaliga ASK1 ma i le HER2-ova fa'amatalaga GC sela. Togafitiga fa'atasi ma K811 fa'aitiitia le lapopo'a o tuma xenograft e ala i le fa'alaloina o fa'ailoga fa'ateleina. |
| CPD100606 | K812 | K812 ose ASK1-specific inhibitor na maua e faʻaumi ai le ola i se faʻataʻitaʻiga o le isumu o le amyotrophic lateral sclerosis. |
| CPD100605 | MSC-2032964A | MSC 2032964A ose malosi ma filifili ASK1 inhibitor (IC50 = 93 nM). E poloka ai le LPS-induced ASK1 ma le p38 phosphorylation i astrocytes isumu aganuʻu ma taofia le neuroinflammation i se faʻataʻitaʻiga EAE kiore. MSC 2032964A o lo'o maua fa'aola fa'alaua'itele ma o'o i le fai'ai. |
| CPD100604 | Selonsertib | Selonsertib, lea e taʻua foi o le GS-4997, o se iniseti faʻaola e mafai ona faʻaogaina o le apoptosis signal-regulating kinase 1 (ASK1), faʻatasi ai ma gaioiga faʻamaʻi, antineoplastic ma anti-fibrotic. GS-4997 taulaʻi ma fusifusia i le catalytic kinase domain o le ASK1 i se ATP-faʻatauva, ma puipuia ai lona phosphorylation ma le faʻagaoioia. GS-4997 e taofia ai le gaosiga o cytokines inflammatory, lalo-faʻatonutonu le faʻaaliga o kenera e aʻafia i fibrosis, taofiofia le tele o apoptosis ma faʻalavelaveina le faʻalauteleina o le telefoni. |
