Etoricoxib

Igoa vaila'au:

5-Chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine

SMILES Code:

O=S(C1=CC=C(C2=CC(Cl)=CN=C2C3=CC=C(C)N=C3)C=C1)(C)=O

InChi Code:

InChI=1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6- 13)24(2,22)23/h3-11H,1-2H3

InChi Key:

MNJVRJDLRVPLFE-UHFFFAOYSA-N

upu autu:

Etoricoxib, Arcoxia, L-791456, MK 0663, MK-0663, 202409-33-4

Solubility:Solu i le DMSO

Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), po'o le -20°C mo taimi uumi (masina)

Fa'amatalaga:

Etoricoxib ose vaila'au fa'ama'i, nonsteroidal anti-inflammatory drug (NSAID) fa'atasi ai ma antipyretic, analgesic, ma mea e mafai ona antineoplastic. Etoricoxib e faʻapipiʻi faapitoa ma faʻalavelaveina le enzyme cyclooxygenase-2 (COX-2), e mafua ai le faʻalavelaveina o le liua o le arachidonic acid i prostaglandins. O le faʻasaina o le COX-2 e mafai ona faʻaosofia ai le apoptosis ma faʻalavelaveina le faʻateleina o le tumo ma le angiogenesis.

Sini: COX-2